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Home / Health / 3 more blood pressure drugs recalled over cancer concern: Here’s what you need to know

3 more blood pressure drugs recalled over cancer concern: Here’s what you need to know



A generic drug company referred to three commonly prescribed blood pressure medications for fears that could include small amounts of a carcinogenic impurity.

The recalled drugs include all valsartan blood pressure drugs, the subject of a series of recalls from several pharmaceutical companies since July.

The generic drug company Mylan Pharmaceuticals recalled 104 batches of three drugs: valsartan tablets, combination tablets with valsartan and amlodipine and combination tablets with valsartan and hydrochlorothiazide.

The tests revealed that valsartan contained traces of N-nitrosodietilamina, or NDEA, a possible human carcinogen, the company said.

Amlodipine and hydrochlorothiazide in autonomous form are not subject to the recall.

Alternative medicines are available. Mylan said that patients should consult their doctor or pharmacist before discontinuing their current medication.

During the recalls, doctors said that stopping a drug without a replacement drug could cause more harm to the patient than continuing the medication.

about the lure can call 888-406-9305. They could see a list of the drugs called up by Mylan here.

The Food and Drug Administration is investigating the cause of the contaminated drugs, originally found in a large factory in China and later in a second factory in India. Both used a similar manufacturing process to produce and supply valsartan to generic pharmaceutical companies around the world.

Tests have shown that the factories produced valsartan that contained N-nitrosodimethylamine, or NDMA, a possible human carcinogen.

tests revealed a second contaminant, NDEA, in some valsartan drugs.

Several pharmaceutical companies have announced the recall of versions of valsartan, irbesartan and losartan.

The recalled drugs are part of a large class of drugs called angiotensin II receptor blockers. These drugs work by enlarging or relaxing the blood vessels, thus lowering blood pressure.

Consumers can view a complete list of FDA updates on recalls here.

FDA officials said that the factories that supplied the contaminated drugs were imported alarm, which means that the drugs are no longer shipped to the United States from these manufacturers.

Factories that use drugs abroad are subject to FDA inspection. They are required to inform legislators about changes in the way they make drug ingredients.

"We do not yet understand the root cause of this problem," said Janet Woodcock, director of the FDA's Center for Drug Assessment and Research. USA TODAY this week. "We understand part of it, we do not understand all the steps that led to this."

Woodcock said that all "sartan" drugs have been tested to ensure that they do not contain impurities. He said no contaminants were detected in the Novartis Diovan, the pharmaceutical brand version of valsartan.

Pharmaceutical companies are aware of the problem and need to do extensive testing, Woodcock said.

"I think these calls will start to leave now," he said. "We have had this import notice in place for quite some time, and companies that buy from these sources have been told to check and recall."

He said that the FDA will make public the results of his investigation into the root cause. The agency will also review its supervision.

"We do not want accidents like this to happen," he said. "So we'll have to look at how we managed the oversight of controlling changes to production processes."

© 201

8 USATODAY.COM


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