Hospitalized COVID-19 Patients with sufficient vitamin D, with a blood level of 25-hydroxyvitamin D of at least 30 ng / mL (a measure of vitamin D status), had a significant reduction in the risk of adverse clinical outcomes including unconsciousness, hypoxia ( body starved of oxygen) and death. They also had lower blood levels of an inflammatory marker (C-reactive protein) and higher blood levels of lymphocytes (a type of immune cell that helps fight infections).
“This study provides direct evidence that vitamin D sufficiency can reduce complications, including cytokine storm (releasing too much protein into the blood too quickly) and eventually death from COVID-19,” explained the Corresponding author Michael F. Holick, PhD, MD, professor of medicine, physiology and biophysics, and molecular medicine at Boston University School of Medicine.
A blood sample to measure vitamin D status (measured serum level of 25-hydroxyvitamin D) was taken from 235 hospitalized patients with COVID-19. These patients were followed up for clinical outcomes including clinical severity of infection, unconsciousness, breathing difficulties resulting in hypoxia and death. Blood was also analyzed for an inflammatory marker (C-reactive protein) and for the number of lymphocytes. The researchers then compared all of these parameters in the patients who were vitamin D deficient with those who were sufficient.
In patients over the age of 40 they observed that those patients who were sufficient for vitamin D were 51.5% less likely to die from the infection than patients who were deficient or insufficient in vitamin D with a level of 25-hydroxyvitamin D less than 30 ng / mL.
Holick, who recently published a study that found that enough vitamin D can reduce the risk of contracting the coronavirus by 54%, believes that having enough vitamin D helps fight the consequences of not just the coronavirus infection but also from other viruses causing diseases of the upper respiratory tract including the flu. “There is great concern that the combination of a flu infection and coronal viral infection could dramatically increase hospitalizations and deaths due to complications from these viral infections.”
According to Holick, this study provides a simple and inexpensive strategy to improve the ability to fight coronavirus and reduce the adverse clinical outcomes of COVID-19, including requiring ventilator support, an overactive immune response leading to cytokine storm and death. . “Because vitamin D deficiency and insufficiency is so prevalent in children and adults in the United States and around the world, especially in the winter months, it is prudent for everyone to take a vitamin D supplement to reduce the risk of getting infected. and have complications from COVID-19. “
Reference: “Vitamin D Sufficiency, a serum 25-hydroxyvitamin D of at least 30 ng / mL reduced the risk of adverse clinical outcomes in patients with COVID-19 infection” by Zhila Maghbooli, Mohammad Ali Sahraian, Mehdi Ebrahimi, Marzieh Pazoki, Samira Kafan, Hedieh Moradi Tabriz, Azar Hadadi, Mahnaz Montazeri, Mehrad Nasiri, Arash Shirvani and Michael F. Holick, 25 September 2020 PLOS ONE.
DOI: 10.1371 / journal.pone.0239799